Protein-based tissue adhesive reduces time to haemostasis in peripheral vascular surgery

Area of Science:

• Vascular Surgery
• Biomaterials
• Surgical Hemostasis

Background:

• Peripheral vascular surgery involves procedures on arteries and veins in the limbs.
• Achieving rapid and effective hemostasis is crucial for patient outcomes.
• Protein-based tissue adhesives offer a potential adjunct for surgical bleeding control.

Purpose of the Study:

• To evaluate the efficacy of Bioglue®, a protein-based tissue adhesive, in reducing time to hemostasis.
• To compare perioperative parameters between patients receiving Bioglue® and those in a control group.
• To assess the impact of Bioglue® on the need for adjunctive stitches and in-hospital bleeding.

Main Methods:

• A randomized controlled trial involving 100 patients undergoing open peripheral vascular surgery across four centers.
• Patients were allocated to either the Bioglue® group (Group Bio) or a control group (Group no-Bio).
• Key outcomes measured included time to hemostasis, number of adjunctive stitches, and in-hospital bleeding events, analyzed using t-tests and Gehan-Breslow-Wilcoxon tests.

Main Results:

• Time to hemostasis was significantly faster in the Bioglue® group (4.4 minutes) compared to the control group (9.6 minutes) (p < 0.001).
• The requirement for adjunctive stitches was substantially lower in the Bioglue® group (16%) versus the control group (50%) (p < 0.001).
• No significant difference was observed in the overall rate of in-hospital bleeding between the two groups (18% in Group Bio vs. 14% in Group no-Bio; p = 0.39).

Conclusions:

• Bioglue® effectively reduces the time to achieve hemostasis and decreases the need for supplementary stitches in peripheral vascular surgery.
• The use of Bioglue® did not alter the overall incidence of perioperative bleeding requiring intervention.
• Larger studies are recommended to confirm these findings and further elucidate the role of Bioglue® in vascular procedures.