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Gut microbiota in multiple sclerosis and animal models

Sean M Schumacher1, William J Doyle1, Kristina Hill1

  • 1Department of Biological Sciences, Boise State University, ID, USA.

The FEBS Journal
|May 31, 2024
PubMed

Insights

Multiple sclerosis (MS) involves immune attacks on the central nervous system (CNS). This review explores how gut microbiota and diet influence MS, inflammation, and gut-brain axis health.

Area of Science:

  • Neuroimmunology
  • Gastroenterology
  • Microbiology

Background:

  • Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease of the central nervous system (CNS).
  • MS is associated with gut microbiome alterations and intestinal barrier dysfunction.
  • The gut-brain axis links diet, gut health, and neuroinflammation.

Purpose of the Study:

  • To review the role of gut microbiota in host inflammatory responses in MS.
  • To discuss the impact of microbial community restoration on MS and gut barrier integrity.

Main Methods:

  • Literature review focusing on gut microbiota, diet, and multiple sclerosis.
  • Analysis of studies on host-microbe interactions and the gut-brain axis in MS models.

Main Results:

  • Gut microbiota composition significantly influences inflammatory responses in MS.
  • Dietary interventions can modulate the gut microbiome, impacting MS progression.
  • Restoring microbial balance may improve gut barrier function and reduce neuroinflammation.

Conclusions:

  • The gut microbiota is a critical factor in MS pathogenesis and progression.
  • Targeting the gut microbiome offers potential therapeutic strategies for MS.
  • Maintaining gut health is essential for managing neuroinflammation in MS.
Keywords:
autoimmunity dietdysbiosismicrobiotamultiple sclerosis

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