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Gut microbiota in multiple sclerosis and animal models.

Sean M Schumacher¹, William J Doyle¹, Kristina Hill¹

¹Department of Biological Sciences, Boise State University, ID, USA.

The FEBS Journal

|May 31, 2024

Summary

Multiple sclerosis (MS) involves immune attacks on the central nervous system (CNS). This review explores how gut microbiota and diet influence MS, inflammation, and gut-brain axis health.

Keywords:

autoimmunity diet dysbiosis microbiota multiple sclerosis

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Area of Science:

Neuroimmunology
Gastroenterology
Microbiology

Background:

Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease of the central nervous system (CNS).
MS is associated with gut microbiome alterations and intestinal barrier dysfunction.
The gut-brain axis links diet, gut health, and neuroinflammation.

Purpose of the Study:

To review the role of gut microbiota in host inflammatory responses in MS.
To discuss the impact of microbial community restoration on MS and gut barrier integrity.

Main Methods:

Literature review focusing on gut microbiota, diet, and multiple sclerosis.
Analysis of studies on host-microbe interactions and the gut-brain axis in MS models.

Main Results:

Gut microbiota composition significantly influences inflammatory responses in MS.
Dietary interventions can modulate the gut microbiome, impacting MS progression.
Restoring microbial balance may improve gut barrier function and reduce neuroinflammation.

Conclusions:

The gut microbiota is a critical factor in MS pathogenesis and progression.
Targeting the gut microbiome offers potential therapeutic strategies for MS.
Maintaining gut health is essential for managing neuroinflammation in MS.