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Updated: Jun 25, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
250
Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers
Yu-Hang Diao1, Si-Qi Rao1, Xin-Peng Shu1
1Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
World Journal of Gastrointestinal Surgery
|May 31, 2024
Summary
Preoperative serum tumor markers, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), alongside age and TNM stage, are key predictors of colorectal cancer (CRC) survival. A new nomogram model effectively evaluates prognosis for nonmetastatic CRC patients.
Area of Science:
- Oncology
- Cancer Research
- Clinical Diagnostics
Background:
- Preoperative serum tumor markers like CEA and CA19-9 are used for colorectal cancer (CRC) diagnosis and monitoring.
- These markers may also hold prognostic value for CRC patients.
Purpose of the Study:
- To investigate the prognostic impact of preoperative serum tumor markers, specifically CEA and CA19-9, on CRC.
- To develop and validate a predictive model for CRC prognosis.
Main Methods:
- Retrospective analysis of 3526 nonmetastatic CRC patients from January 2011 to January 2020.
- Cox regression analysis identified independent prognostic factors.
- A prognostic nomogram model was constructed and internally validated.
Main Results:
- Age, TNM classification, preoperative CEA, and CA19-9 were identified as independent prognostic factors.
- The nomogram model demonstrated good performance with AUCs of 0.655 (development) and 0.658 (validation).
- Calibration plots confirmed the model's significant predictive accuracy.
Conclusions:
- A nomogram integrating age, TNM stage, preoperative CEA, and CA19-9 levels was successfully developed.
- This model aids in evaluating the overall survival of patients with nonmetastatic CRC.
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