Clinical characteristics and risk factors of post-operative intestinal flora disorder following laparoscopic colonic surgery: A propensity-score-matching analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Intestinal flora disorder (IFD) affects 9% of patients after laparoscopic colonic surgery. Pre-operative obstruction and post-operative antibiotics are risk factors, while parenteral nutrition is protective.
Area Of Science
- Gastroenterology
- Surgical Oncology
- Microbiome Research
Background
- Intestinal flora disorder (IFD) is a common complication after laparoscopic colonic surgery.
- There is a lack of standardized diagnostic and treatment criteria for IFD.
Purpose Of The Study
- To investigate the clinical features of IFD.
- To identify risk factors associated with IFD development after laparoscopic colonic surgery.
Main Methods
- Propensity-score-matching (PSM) was used to analyze patients undergoing laparoscopic surgery for colon cancer.
- Patients were divided into IFD and non-IFD groups to compare clinical characteristics and treatments.
- Multivariate regression analysis identified independent risk factors and protective factors for IFD.
Main Results
- The incidence of IFD was 9.0% post-laparoscopic surgery.
- Common symptoms included diarrhea and abdominal discomfort, typically appearing on postoperative days 3-4.
- Independent risk factors for IFD were pre-operative intestinal obstruction (OR=2.79) and post-operative antibiotics (OR=8.57), while pre-operative parenteral nutrition was protective (OR=0.12).
Conclusions
- A stepwise treatment approach involving probiotics, vancomycin, and decompression may be effective for IFD.
- Patients with pre-operative obstruction or those receiving early post-operative antibiotics require close monitoring.
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