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Antimicrobial resistance pattern and uropathogens distribution in children visiting a referral hospital in Mogadishu

Abdikarin Ahmed Mohamed1,2, Yavuz Bastug1, Cem Senol1

  • 1Department of Pediatrics & Child Health, Mogadishu Somalia Turkish Training & Research Hospital, Mogadishu, Somalia.

Future Science OA
|May 31, 2024
PubMed

Insights

Pediatric urinary tract infections (UTIs) are common, with Escherichia coli and Klebsiella pneumoniae being the most frequent causes. Many pathogens show multidrug resistance, highlighting the need for updated treatment guidelines.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Epidemiology and antimicrobial susceptibility of pediatric urinary tract infections (UTIs) are understudied in developing nations.
  • Urinary tract infections are a significant health concern in children, necessitating research into causative agents and resistance patterns.

Purpose of the Study:

  • To investigate the distribution of uropathogens and their antimicrobial resistance patterns in pediatric patients.
  • To address the scarcity of data on pediatric UTIs in developing countries.

Main Methods:

  • A retrospective study analyzed urine culture data from 840 pediatric patients over four years.
  • Identified common uropathogens and assessed their susceptibility to various antimicrobial agents.

Main Results:

  • The prevalence of culture-proven pediatric UTIs was 17.6%.
  • Escherichia coli (48%) and Klebsiella pneumoniae (16.2%) were the predominant pathogens.
  • A significant multidrug-resistant (MDR) pattern was observed in 27% of isolates, with high resistance to trimethoprim-sulfamethoxazole (79.7%).

Conclusions:

  • Escherichia coli and Klebsiella pneumoniae are the primary causative agents of pediatric UTIs in this population.
  • The high prevalence of multidrug-resistant pathogens underscores the challenges in treating pediatric UTIs and the need for careful antibiotic selection.

Keywords:
antimicrobial resistancemultidrug-resistant patternspediatric urinary tract infection

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