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Prognostic scores in primary biliary cholangitis
Ramzi Tababi1, Soumaya Mrabet1, Imen Akkari1
1Department of Gastroenterology, Farhat Hached University Hospital, Sousse, 4000, Tunisia.
Future Science OA
|May 31, 2024
Summary
Prognostic scores effectively predict treatment response and long-term liver complications in primary biliary cholangitis (PBC) patients receiving ursodeoxycholic acid (UDCA). These scores aid clinicians in managing PBC and anticipating disease progression.
Area of Science:
- Hepatology
- Clinical Medicine
- Biochemistry
Background:
- Primary biliary cholangitis (PBC) is a chronic liver disease.
- Ursodeoxycholic acid (UDCA) is a primary treatment for PBC.
- Predicting treatment response and long-term outcomes is crucial for managing PBC patients.
Purpose of the Study:
- To evaluate the utility of established prognostic scores in predicting biochemical response (BR) to UDCA.
- To assess the ability of these scores to predict long-term liver-related complications in PBC patients.
Main Methods:
- Retrospective single-center study of 50 female PBC patients on UDCA.
- Biochemical response (BR) defined by Paris II criteria.
- Calculation of APRI, ALBI, Mayo, GLOBE, and UK-PBC scores.
- Median follow-up of 76 months for liver-related complications.
Main Results:
- 64% of patients achieved BR to UDCA.
- 40% of patients experienced liver-related complications during follow-up.
- All evaluated scores demonstrated good prediction for BR (concordance statistics: 0.76-0.94).
- Scores showed excellent negative predictive values for 5-year liver complications (concordance statistics: 0.73-0.89).
Conclusions:
- Prognostic scores are effective tools for predicting UDCA biochemical response in PBC.
- These scores accurately predict long-term liver-related complications in PBC patients.
- Clinical implementation of these prognostic scores is recommended for improved patient management.
