Prognostic scores in primary biliary cholangitis

Aim: Evaluating prognostic scores' utility in predicting ursodeoxycholic acid (UDCA) biochemical response (BR) and long-term liver-related complications in primary biliary cholangitis (PBC) patients. Patients & methods: This retrospective single-center study included 50 predominantly female PBC patients (median age: 56) on UDCA treatment. BR was defined by Paris II criteria. Liver-related complications during a median 76-month follow-up were assessed. APRI, ALBI, Mayo, GLOBE and UK-PBC scores were calculated. Results: 64% achieved BR, while 40% experienced liver-related complications. All scores showed good BR prediction (concordance statistics: 0.76-0.94) and excellent negative predictive values for 5-year liver complications (concordance statistics: 0.73-0.89). Conclusion: Implementing these scores in clinical practice is encouraged due to their effectiveness in predicting BR- and liver-related events.