Use of Botulinum Toxin Injections in the Treatment of Cold Intolerance

Area of Science:

• Regenerative Medicine
• Neurology
• Plastic Surgery

Background:

• Cold intolerance in extremities is a challenging condition in post-trauma patients with no established treatment consensus.
• Existing treatments often yield suboptimal results, necessitating novel therapeutic approaches.

Observation:

• Two patients with post-traumatic cold intolerance received injections of botulinum toxin type A around the palmar digital neurovascular bundle.
• The injections were administered bilaterally to the affected digits.

Findings:

• Both patients experienced significant improvement in cold intolerance symptoms following botulinum toxin type A injections.
• One patient was discharged, while the other continues routine follow-up, with potential for annual injections during winter.

Implications:

• Botulinum toxin type A presents a promising, low-risk treatment modality for alleviating cold intolerance in post-trauma patients.
• These findings suggest a potential new therapeutic avenue for improving quality of life in individuals suffering from extremity cold sensitivity after injury.