Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.8K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

259
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
259

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of the influence of the transducer and its coupling layer on round window stimulation.

Acta of bioengineering and biomechanics·2017
Same author

New alkenylated tetrahydropyran derivatives from the marine sediment-derived fungus Westerdykella dispersa and their bioactivities.

Fitoterapia·2017
Same author

Capturing the Unconventional Metallofullerene M@C<sub>66</sub> by Trifluoromethylation: A Theoretical Study.

Chemphyschem : a European journal of chemical physics and physical chemistry·2017
Same author

Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins.

Cell stem cell·2017
Same author

Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice.

Neurobiology of disease·2017
Same author

Dope dyeing of lyocell fiber with NMMO-based carbon black dispersion.

Carbohydrate polymers·2017

Related Experiment Video

Updated: Jun 25, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

10.9K

Association between systemic inflammatory markers and chronic obstructive pulmonary disease: A population-based

Dongru Du1,2, Guangyue Zhang2, Dan Xu1

  • 1Department of Pulmonary and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu, 610041, China.

Heliyon
|May 31, 2024
PubMed
Summary

Inflammatory indices like SII, NLR, PLR, and PPN correlate with chronic obstructive pulmonary disease (COPD), while LMR shows a negative association. These associations differ between spirometry-based and questionnaire-based COPD diagnoses.

Keywords:
AssociationChronic obstructive pulmonary diseaseSystematic inflammation

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

419
Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

27.6K

Related Experiment Videos

Last Updated: Jun 25, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

10.9K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

419
Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

27.6K

Area of Science:

  • Medical research
  • Pulmonology
  • Immunology

Background:

  • Chronic obstructive pulmonary disease (COPD) is a major global health concern.
  • Inflammation plays a critical role in COPD pathogenesis.
  • Novel biomarkers for COPD assessment are needed.

Purpose of the Study:

  • To investigate the correlation between various inflammatory indices and COPD.
  • To assess the relationship between systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), product of platelet and neutrophil count (PPN), and lymphocyte-to-monocyte ratio (LMR) with COPD.
  • To explore potential differences in these associations based on COPD diagnostic criteria.

Main Methods:

  • Cross-sectional study utilizing the National Health and Nutrition Examination Survey (NHANES) database (2007-2018).
  • Calculation and log2-transformation of SII, NLR, PLR, PPN, and LMR from blood cell counts.
  • COPD diagnosis based on questionnaire or spirometry.
  • Multivariate logistic regression, sensitivity, subgroup, and interaction analyses were performed.

Main Results:

  • A total of 23,875 participants, including 1000 COPD patients, were analyzed.
  • Positive associations were found between SII, NLR, PLR, PPN, and COPD.
  • A negative association was observed between LMR and COPD.
  • Specific indices showed stronger correlations with spirometry-based COPD (SII, PLR, PPN) versus questionnaire-based COPD (NLR, LMR).

Conclusions:

  • Significant associations exist between multiple inflammatory indices and COPD.
  • Heterogeneity in these associations was noted between spirometry-defined and questionnaire-defined COPD.
  • Further research is warranted to validate these findings and explore their clinical implications.