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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
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Potential use of antioxidants for the treatment of chronic inflammatory diseases
Alexander V Blagov1, Volha I Summerhill2, Vasily N Sukhorukov1,3
1Institute of General Pathology and Pathophysiology, Moscow, Russia.
Frontiers in Pharmacology
|May 31, 2024
Summary
Oxidative stress, an imbalance between oxidants and antioxidants, contributes to chronic inflammation and diseases. Natural and synthetic antioxidants show promise as therapeutic agents for these conditions.
Area of Science:
- Biochemistry
- Pharmacology
- Pathophysiology
Background:
- Oxidative stress arises from excessive reactive oxidant species overwhelming antioxidant defenses.
- It causes biomolecular damage, disrupts signaling, and can lead to cell death, contributing to chronic inflammatory diseases.
- Oxidative stress and chronic inflammation are interconnected, exacerbating each other.
Purpose of the Study:
- To review natural and synthetic antioxidants as potential therapeutic agents.
- To explore antioxidants for treating chronic inflammatory diseases.
- To highlight metalloenzymes as models for catalytic drug design.
Main Methods:
- Literature review of natural and synthetic antioxidants.
- Analysis of the role of oxidative stress in chronic inflammation.
- Examination of metalloenzymes (superoxide dismutase, catalase, glutathione peroxidase) as therapeutic targets.
Main Results:
- Oxidative stress is implicated in cardiovascular diseases, diabetes, cancer, and neurodegeneration.
- Previous antioxidant trials in humans have yielded mixed or negative results.
- Natural compounds and enzyme-mimicking catalysts are promising for anti-inflammatory drug development.
Conclusions:
- Targeting oxidative stress remains a viable strategy for developing novel anti-inflammatory drugs.
- Natural antioxidants and catalytic drugs inspired by metalloenzymes offer potential therapeutic benefits.
- Further research is needed to develop safe and effective antioxidant-based therapies for chronic inflammatory conditions.
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