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Updated: Jun 25, 2025

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
Published on: May 28, 2021
The stratum corneum barrier: impaired function in relation to associated lipids and proteins
Jie Chen1, Changjie Liu2, Yuan Yang2
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Xuhui, District, China.
None:
The skin is the largest organ of the human body and is widely considered to be the first-line defense of the body, providing essential protection against mechanical, physical, and chemical damage. Keratinocytes are the primary cells of the outer layer of the epidermis, which acts as a mechanical and permeability barrier. The epidermis is a permanently renewed tissue where undifferentiated keratinocytes located at the basal layer proliferate and migrate to the overlying layers. Here we report that some components of keratinocytes affect the formation and differentiation of the stratum corneum, which is the most specialized layer of the epidermis.
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