18F-fluoro-ethyl-tyrosine PET co-registered with MRI in patients with persisting acromegaly
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Summary
This summary is machine-generated.18F-fluoro-ethyl-tyrosine (FET) PET-CT co-registered with MRI (FET-PET/MRI<sup>CR</sup>) aids persistent acromegaly management. This imaging modality provided crucial information for surgical decision-making, leading to improved patient outcomes.
Area Of Science
- Endocrinology
- Nuclear Medicine
- Radiology
Background
- Persistent acromegaly often requires complex management strategies.
- Standard magnetic resonance imaging (MRI) may not always provide sufficient detail for surgical planning in these cases.
Purpose Of The Study
- To evaluate the utility of 18F-fluoro-ethyl-tyrosine (FET) positron emission tomography-computed tomography (PET-CT) co-registered with MRI (FET-PET/MRI<sup>CR</sup>) in patients with persistent acromegaly.
- To assess its role in supporting multidisciplinary team decision-making for surgical intervention.
Main Methods
- Prospective case series of ten patients with insufficiently controlled acromegaly.
- FET-PET/MRI<sup>CR</sup> was employed when conventional MRI and multidisciplinary evaluation lacked clarity for surgical decisions.
Main Results
- FET-PET/MRI<sup>CR</sup> revealed suspicious tracer uptake in all patients, identifying new foci in four.
- Surgical re-exploration occurred in nine patients, with FET-PET/MRI<sup>CR</sup> findings confirmed intraoperatively (78%) and histologically (67%).
- Significant IGF-1 decrease (89%) and clinical improvement were observed; 67% achieved optimal outcomes.
Conclusions
- FET-PET/MRI<sup>CR</sup> is a valuable new imaging tracer for persistent acromegaly.
- It provides additional information to aid multidisciplinary pituitary teams in decision-making, particularly when MRI is inconclusive.
- The technique contributes to improved patient management and outcomes.
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