RETRACTION: 5-Lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking

    Abstract

    Insights

    This study on 5-lipoxygenase and apoptosis has been retracted due to duplicated and manipulated data in key figures, impacting the interpretation of results.

    Area of Science:

    • Molecular Biology
    • Cellular Biology
    • Biochemistry

    Context:

    • Concerns were raised regarding data integrity in a published FASEB Journal article.
    • An investigation into the figures of the study was conducted following third-party concerns.

    Purpose:

    • To investigate allegations of data duplication and manipulation in the study figures.
    • To determine the validity of the presented data and its impact on the study's conclusions.

    Summary:

    • The article "5-Lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking" has been retracted.
    • Retraction is due to duplicated and manipulated data in multiple figures (1A, F; 2E; 3A-C; 5B; 6A, B).
    • Authors could not provide satisfactory explanations or original data, leading to retraction by agreement.

    Impact:

    • The identified data issues affect the interpretation of results concerning 5-lipoxygenase, genotoxic stress, and apoptosis.
    • Retraction highlights the importance of data integrity and verification in scientific publishing.
    • This retraction underscores the need for rigorous data validation processes in experimental research.

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