Related Experiment Video
Updated: Jun 25, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
RETRACTION: 5-Lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking
Retraction:
A. Catalano, P. Caprari, S. Soddu, A. Procopio, and M. Romano, "5-Lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking," FASEB Journal 18, no. 14 (2004): 1740-1742, https://doi.org/10.1096/fj.04-2258fje. The above article, published online on September 16, 2004 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Dr. Loren E. Wold; the Federation of American Societies for Experimental Biology; and Wiley Periodicals LLC. Following publication, concerns were raised by third parties regarding several figures, which were then investigated further. The authors were unable to provide a satisfactory explanation and could not provide the original data due to the time passed since publication. This retraction was therefore agreed because of the presence of duplicated and manipulated data elements in Figures 1A, F; 2E; 3A-C; 5B; and 6A, B, affecting the interpretation of the data and the results presented. A.C. has been informed of the decision to retract. P.C., A.P., S.S., and M.R. collaborated during the investigation, agreed to the retraction, and stated that they were not involved in processing the raw data into figures. M.R. and A.P. also stated that none of the experiments reported in the figures listed above were done in their laboratories.
Insights
This study on 5-lipoxygenase and apoptosis has been retracted due to duplicated and manipulated data in key figures, impacting the interpretation of results.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Context:
- Concerns were raised regarding data integrity in a published FASEB Journal article.
- An investigation into the figures of the study was conducted following third-party concerns.
Purpose:
- To investigate allegations of data duplication and manipulation in the study figures.
- To determine the validity of the presented data and its impact on the study's conclusions.
Summary:
- The article "5-Lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking" has been retracted.
- Retraction is due to duplicated and manipulated data in multiple figures (1A, F; 2E; 3A-C; 5B; 6A, B).
- Authors could not provide satisfactory explanations or original data, leading to retraction by agreement.
Impact:
- The identified data issues affect the interpretation of results concerning 5-lipoxygenase, genotoxic stress, and apoptosis.
- Retraction highlights the importance of data integrity and verification in scientific publishing.
- This retraction underscores the need for rigorous data validation processes in experimental research.
More Related Videos
08:35Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles
Published on: January 4, 2012
09:32Procedure and Key Optimization Strategies for an Automated Capillary Electrophoretic-based Immunoassay Method
Published on: September 10, 2017
Related Concept Videos
Abnormal Proliferation
DNA Damage can Stall the Cell Cycle
The Intrinsic Apoptotic Pathway
Negative Regulator Molecules
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...