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Risk factors for peri-megaprosthetic joint infections in tumor surgery: A systematic review
Vasileios Karampikas1, Panayiotis Gavriil1, Stavros Goumenos1
1First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, 41 Ventouri Street, 15562, Holargos, Athens, Greece.
Background:
Peri-megaprosthetic joint infections (PJI) in tumor surgery are complex and challenging complications that significantly impact the outcomes of the patients. The occurrence of PJI poses a substantial threat to the success of these operations. This review aims to identify and summarize the risk factors associated with PJI in tumor surgery with megaprosthetic reconstruction as well as to determine the overall risk of PJI in limb salvage surgery.
Methods:
A thorough examination of published literature, scrutinizing the incidence of PJI in tumor prostheses after limb salvage surgery was done. Research studies that documented the incidence of PJI in tumor patients who underwent limb salvage surgery, and explored the risk factors associated with the occurrence of PJI were deemed eligible.
Results:
A total of 15 studies were included in the analysis and underwent comprehensive examination. After the exploration of key parameters, several significant risk factors for PJI concerning the type of implant coating, surgical site characteristics, patient demographics, and procedural factors were recorded.
Discussion:
The findings underscore the need for a nuanced approach in managing tumor patients undergoing limb salvage surgery and megaprosthetic reconstruction, with emphasis on individualized risk assessments and individualized preventive strategies.
Insights
Identifying risk factors for peri-megaprosthetic joint infections (PJI) after limb salvage surgery is crucial for patient outcomes. This review summarizes key PJI risks in tumor surgery with megaprosthetic reconstruction.
Area of Science:
- Orthopedic Surgery
- Oncology
- Infectious Diseases
Background:
- Peri-megaprosthetic joint infections (PJI) are significant complications following tumor surgery with megaprosthetic reconstruction.
- PJI severely impacts patient outcomes and threatens the success of limb salvage procedures.
Purpose of the Study:
- To identify and summarize risk factors for PJI in tumor surgery involving megaprosthetic reconstruction.
- To determine the overall incidence of PJI in patients undergoing limb salvage surgery for bone tumors.
Main Methods:
- A systematic literature review was conducted to analyze the incidence of PJI in tumor prostheses after limb salvage surgery.
- Eligible studies documented PJI incidence and explored associated risk factors in tumor patients.
Main Results:
- Fifteen studies were included in the comprehensive analysis.
- Significant risk factors for PJI were identified, including implant coating type, surgical site characteristics, patient demographics, and procedural factors.
Conclusions:
- Management of tumor patients undergoing limb salvage surgery requires individualized risk assessment.
- Tailored preventive strategies are essential to mitigate the risk of PJI in these complex cases.
