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Updated: Jun 25, 2025

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Advances in the synthesis of rearranged homoisoflavonoids
Felipe C Demidoff1, Paulo R R Costa2, Guilherme S Caleffi2
1Instituto Multidisciplinar de Química, Universidade Federal do Rio de Janeiro, 27930-560 Macaé, Brazil.
Abstract:
Rearranged homoisoflavonoids constitute a unique group of natural products, renowned for their structural diversity and complexity. These compounds, derived from modifications in the 3-benzylchroman skeleton, are categorized into four subclasses: brazilin, caesalpin, protosappanin, and scillascillin homoisoflavonoids. This review examines the advancements in the total synthesis of these complex structures, aiming to highlight the challenges and opportunities encountered. A comparative analysis of the strategies employed thus far to synthesize these compounds provides a comprehensive understanding of the progress in this field.
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