Harnessing an amide-based covalent organic framework in solid-phase extraction for chlorophenol analysis in...

Area of Science:

• Materials Science
• Analytical Chemistry
• Environmental Science

Background:

• Covalent organic frameworks (COFs) are emerging porous materials with tunable properties.
• Chlorophenols are common industrial pollutants requiring sensitive detection methods.

Purpose of the Study:

• To synthesize and characterize an amide-based COF for solid-phase extraction (SPE).
• To develop and optimize an SPE method for chlorophenol determination in industrial wastewater.

Main Methods:

• Amide-based COF synthesis via 1,3,5-trimesoyl chloride and ethylenediamine.
• COF characterization using FTIR, NMR, XRD, SEM, EDX, and BET analysis.
• SPE optimization using response surface methodology (Box-Behnken design) coupled with HPLC-UV detection.

Main Results:

• Successful synthesis and characterization of the amide-based COF.
• Optimized SPE method demonstrated good linearity (R² > 0.998) over 0.003-10 µg/mL.
• Low limits of detection (0.001-0.01 µg/mL) and high repeatability (RSD < 4.7%) were achieved.

Conclusions:

• The developed amide-based COF is a promising adsorbent for chlorophenol SPE.
• The optimized method provides accurate and precise determination of chlorophenols in industrial wastewater.
• This approach offers an effective solution for environmental monitoring of chlorophenols.