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Published on: January 7, 2019
Transcutaneous auricular vagus nerve stimulation for epilepsy
Qing Zhang1, Xue Luo2, Xiao-Hui Wang3
1Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, China.
Transcutaneous auricular vagus nerve stimulation (taVNS) shows promise for treating epilepsy, with improved response rates and EEG changes in patients. Animal studies confirm taVNS effectively reduces epileptic behavior and seizure frequency.
Area of Science:
- Neurology
- Medical Devices
- Integrative Medicine
Background:
- Transcutaneous vagus nerve stimulation (tVNS) is explored for epilepsy treatment.
- Auricular acupoint therapy, a form of vagus nerve stimulation, lacks comprehensive review.
- This review categorizes auricular acupoint therapy as transcutaneous auricular vagus nerve stimulation (taVNS).
Purpose of the Study:
- Assess the efficacy of taVNS in patients with epilepsy (PWE).
- Analyze preclinical data on taVNS's antiepileptic effects.
- Evaluate taVNS's impact on electroencephalogram (EEG) changes in PWE.
Main Methods:
- Systematic review and meta-analysis of nine clinical and eight preclinical studies.
- Searched multiple databases (MEDLINE, EMBASE, Web of Science, Scopus, Chinese databases) up to June 10, 2023.
- Utilized PRISMA 2020 checklist for study quality assessment.
Main Results:
- taVNS demonstrated a significantly higher response rate in PWE compared to control treatments (OR = 2.94).
- The taVNS group exhibited more pronounced EEG changes than the control group (OR = 2.17).
- Preclinical studies showed significant improvements in epileptic behavior (SMD = -4.78) and seizure frequency (SMD = -5.06) with taVNS.
Conclusions:
- Patients with epilepsy (PWE) may experience benefits from transcutaneous auricular vagus nerve stimulation (taVNS).
- taVNS proves effective in improving epileptic behaviors in animal models.
- Further research into taVNS for epilepsy management is warranted.
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