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Probability maps for deep learning-based head and neck tumor segmentation: Graphical User Interface design and test.

Alessia De Biase1, Liv Ziegfeld2, Nanna Maria Sijtsema3

  • 1Department of Radiation Oncology, University Medical Center Groningen (UMCG), 9700 RB, Groningen, the Netherlands; Data Science Center in Health (DASH), University Medical Center Groningen (UMCG), 9700 RB, Groningen, the Netherlands.

Computers in Biology and Medicine
|May 31, 2024
PubMed
Summary
This summary is machine-generated.

Deep learning-generated tumor probability maps offer an intuitive and explainable alternative for head and neck cancer segmentation, improving radiation oncologist workflows. This method enhances tumor auto-segmentation model generalizability.

Keywords:
Adaptive segmentationClinical explainabilityDeep learningHead and neck cancerHuman-centered artificial intelligenceTumor segmentation

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Area of Science:

  • Medical Imaging
  • Artificial Intelligence in Oncology
  • Radiation Therapy Planning

Background:

  • Manual tumor segmentation in head and neck cancer is subjective due to variations in imaging.
  • Variability in manual contours limits the generalizability of deep learning (DL) auto-segmentation models.
  • A novel DL-based method was developed to output tumor probability maps instead of fixed contours.

Purpose of the Study:

  • To demonstrate the clinical relevance and intuitiveness of DL-generated probability maps for tumor segmentation.
  • To present a more suitable solution for radiation oncologists in gross tumor volume segmentation.
  • To improve the performance of DL-based tumor auto-segmentation models.

Main Methods:

  • Development of a DL-based method producing voxel-wise tumor probability maps.
  • Design of a graphical user interface (GUI) for interacting with probability maps.
  • Conducting a user study with nine radiation oncology experts assessing usability and functionality.

Main Results:

  • Radiation oncologists preferred a rainbow colormap for intuitive visualization of tumor probability maps.
  • A slider feature for threshold selection was appreciated for contour generation.
  • The prototype demonstrated excellent usability and positive integration into clinical workflows.

Conclusions:

  • DL-generated tumor probability maps are explainable, transparent, and intuitive.
  • These maps represent a superior alternative to single-output tumor segmentation models.
  • The approach enhances tumor auto-segmentation and assists radiation oncologists.