Related Experiment Video

Updated: Jun 25, 2025

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

3.6K

Aptamer-mediated therapeutic strategies provide a potential approach for cancer

Bingshuo Yan1, Yuting Li1, Shiming He1

  • 1School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, People's Republic of China.

International Immunopharmacology
|May 31, 2024
PubMed

Insights

Aptamers offer precise tumor targeting for advanced cancer therapies. This review explores aptamer-nanodrugs, photodynamic, photothermal, and immunotherapy strategies to improve treatment efficacy.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Conventional tumor treatments like surgery, chemotherapy, and radiation have limitations and side effects.
  • Aptamers, with their high affinity and targeting capabilities, are crucial for advanced drug delivery systems.
  • Bridging basic research and clinical application, aptamers are key in developing novel cancer therapies.

Purpose of the Study:

  • To review the latest advancements in aptamer-mediated nanodrugs for tumor treatment.
  • To explore aptamer-based strategies in photodynamic therapy, photothermal therapy, and immunotherapy.
  • To assess the potential of aptamer-mediated therapies for accurate and enhanced tumor treatment.

Main Methods:

  • Literature review of recent progress in aptamer-mediated nanomedicine.
  • Analysis of aptamer applications in various cancer therapeutic modalities.
  • Exploration of aptamer-based targeting mechanisms in nanodrug delivery.

Main Results:

  • Aptamer-nanodrugs demonstrate significant potential for targeted delivery.
  • Aptamer-mediated photodynamic, photothermal, and immunotherapy show promising results in preclinical studies.
  • Integration of aptamers enhances the precision and efficacy of diverse cancer treatment strategies.

Conclusions:

  • Aptamer-mediated therapies represent a significant advancement in precision oncology.
  • These strategies offer improved therapeutic outcomes with potentially reduced side effects.
  • Further research into aptamer-based approaches could revolutionize cancer patient treatment.
Keywords:
AptamerImmunotherapyNanodrugsPhotodynamic therapyPhotothermal treatment

More Related Videos

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy09:56

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

488
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

1.8K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
514
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
25.4K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K