Advances and challenges in serratiopeptidase topical formulation

Area of Science:

• Biochemistry
• Pharmacology
• Drug Delivery Systems

Background:

• Proteolytic enzymes like serratiopeptidase (SRP) are crucial for metabolic processes and protein digestion.
• Naturally produced in the body or found in certain diets, SRP faces challenges in conventional drug delivery due to solubility, stability, and permeability issues.
• Its proteinaceous and hydrophilic nature makes it susceptible to gastrointestinal degradation and limits intestinal barrier penetration.

Purpose of the Study:

• To review various topical formulations of serratiopeptidase.
• To explore the potential of topical SRP as an effective anti-inflammatory agent.
• To address the limitations of traditional oral delivery methods for serratiopeptidase.

Main Methods:

• Review of existing studies on serratiopeptidase topical formulations.
• Analysis of the pharmacokinetic and pharmacodynamic properties of topical SRP.
• Comparison of anti-inflammatory effects of topical SRP with topical NSAIDs.

Main Results:

• Topical formulations can bypass gastric degradation and enhance direct permeation through the skin.
• Topical SRP demonstrates potentially superior anti-inflammatory effects compared to topical NSAIDs.
• SRP topical formulations show promise for treating localized inflammation effectively.

Conclusions:

• Topical delivery of serratiopeptidase offers a viable strategy to overcome its inherent limitations.
• Serratiopeptidase topical formulations represent a promising alternative for managing local inflammatory conditions.
• Further research into various topical formulations is warranted to optimize delivery and therapeutic outcomes.