Association Between Preoperative Osteopenia and Prognosis in Breast Cancer Patients
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View abstract on PubMed
Summary
This summary is machine-generated.Preoperative osteopenia, a loss of bone mineral density, is linked to increased breast cancer recurrence, especially in premenopausal women. This finding highlights osteopenia as a significant prognostic factor for breast cancer survival.
Area Of Science
- Oncology
- Radiology
- Bone Metabolism
Background
- Osteopenia, characterized by reduced bone mineral density (BMD), is an emerging prognostic factor in various cancers.
- The prognostic role of preoperative osteopenia in breast cancer patients is not well-established.
- Clarifying this association is crucial for improving breast cancer patient outcomes.
Purpose Of The Study
- To investigate the clinical significance of preoperative osteopenia as a prognostic factor in primary breast cancer.
- To determine the relationship between osteopenia and patient survival, considering menopausal status.
Main Methods
- Retrospective analysis of 532 primary breast cancer patients (Stage I-III) diagnosed between 2009 and 2017.
- Osteopenia assessment using average pixel density (Hounsfield unit) in the 11th thoracic vertebra on preoperative CT scans.
- Evaluation of recurrence-free survival (RFS) and overall survival (OS) in relation to osteopenia status and menopausal status.
Main Results
- Osteopenia was present in 35.0% of patients.
- Patients with osteopenia had significantly worse RFS (p=0.0275) but not OS.
- In premenopausal patients, osteopenia was associated with significantly worse RFS and OS (p=0.0094 and p=0.0264, respectively) and was an independent prognostic factor for RFS (p=0.0266).
Conclusions
- Preoperative osteopenia is independently associated with an increased risk of breast cancer recurrence.
- The prognostic impact of osteopenia is particularly significant in premenopausal breast cancer patients.
- These findings suggest that osteopenia assessment may aid in risk stratification for breast cancer recurrence.
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