Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
Positron Emission Tomography01:29

Positron Emission Tomography

4.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.2K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

107
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
107
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

91
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
91
  1. Home
  3. Effect Of Epidermal Growth Factor Receptor Mutation On Positron Emission Tomography/computed Tomography In Lung Cancer.
  1. Home
  3. Effect Of Epidermal Growth Factor Receptor Mutation On Positron Emission Tomography/computed Tomography In Lung Cancer.

Related Experiment Video

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

17.9K

Effect of Epidermal Growth Factor Receptor Mutation on Positron Emission Tomography/Computed Tomography in Lung

Ji Sun Park1, Ha Young Park2, Yunseon Choi3

  • 1Department of Nuclear Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea.

Anticancer Research
|May 31, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Epidermal growth factor receptor (EGFR) mutations in lung cancer are linked to lower F-18 FDG PET/CT SUVmax values and reduced recurrence rates. These mutations suggest a correlation with low-glucose metabolism in non-small-cell lung cancer patients.

Keywords:
EGFR mutationPETlung cancerperineural invasionrecurrence

More Related Videos

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
13:34

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

Published on: April 6, 2016

10.2K
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.1K

Related Experiment Videos

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

17.9K
A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
13:34

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

Published on: April 6, 2016

10.2K
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.1K

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Molecular Diagnostics

Background:

  • Epidermal growth factor receptor (EGFR) mutations are key drivers in non-small-cell lung cancer (NSCLC).
  • Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) is a standard imaging modality for lung cancer staging and assessment.
  • Understanding the relationship between EGFR mutations and imaging characteristics is crucial for personalized treatment strategies.

Purpose of the Study:

  • To investigate the impact of EGFR mutations on F-18 FDG PET/CT findings in lung cancer patients.
  • To correlate EGFR mutation status with pathological features and postoperative outcomes, including recurrence and survival.

Main Methods:

  • Retrospective analysis of 210 lung cancer patients diagnosed via F-18 FDG PET/CT.
  • EGFR mutation testing performed on biopsy specimens from 78 patients with confirmed mutations.
  • Analysis of surgical pathological findings and postoperative recurrence data for 69 patients.

    • Main Results:

    • Patients with EGFR mutations showed lower maximum standardized uptake values (SUVmax) on F-18 FDG PET/CT (<10).
    • Adenocarcinoma histology and lower recurrence rates were observed in patients with EGFR mutations.
    • Disease-free survival was significantly longer in patients harboring EGFR mutations compared to those without.

    Conclusions:

    • EGFR mutations in NSCLC are associated with lower glucose metabolism, reflected in reduced F-18 FDG uptake.
    • EGFR mutation status can predict imaging characteristics and influence postoperative recurrence risk and survival outcomes.
    • F-18 FDG PET/CT SUVmax may serve as a potential imaging biomarker for EGFR mutation status in lung cancer.