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The Relationship Between the Molecular Phenotypes of Brain Gliomas and the Imaging Features and Sensitivity of
Y-R Huang1, H-Q Fan1, Y-Y Kuang1
1Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Abstract:
Gliomas are the most common primary malignant tumors of the brain, accounting for about 80% of all central nervous system malignancies. With the development of molecular biology, the molecular phenotypes of gliomas have been shown to be closely related to the process of diagnosis and treatment. The molecular phenotype of glioma also plays an important role in guiding treatment plans and evaluating treatment effects and prognosis. However, due to the heterogeneity of the tumors and the trauma associated with the surgical removal of tumor tissue, the application of molecular phenotyping in glioma is limited. With the development of imaging technology, functional magnetic resonance imaging (MRI) can provide structural and function information about tumors in a noninvasive and radiation-free manner. MRI is very important for the diagnosis of intracranial lesions. In recent years, with the development of the technology for tumor molecular diagnosis and imaging, the use of molecular phenotype information and imaging procedures to evaluate the treatment outcome of tumors has become a hot topic. By reviewing the related literature on glioma treatment and molecular typing that has been published in the past 20 years, and referring to the latest 2020 NCCN treatment guidelines, summarizing the imaging characteristic and sensitivity of radiotherapy and chemotherapy of different molecular phenotypes of glioma. In this article, we briefly review the imaging characteristics of different molecular phenotypes in gliomas and their relationship with radiosensitivity and chemosensitivity of gliomas.
Insights
This review explores how advanced MRI imaging can reveal glioma molecular phenotypes, aiding in predicting treatment response to radiotherapy and chemotherapy for better brain tumor management.
Area of Science:
- Neuro-oncology
- Medical Imaging
- Molecular Biology
Background:
- Gliomas are the most common primary malignant brain tumors, comprising 80% of CNS malignancies.
- Molecular phenotypes are crucial for glioma diagnosis, treatment planning, and prognosis assessment.
- Tumor heterogeneity and surgical biopsy limitations hinder molecular phenotyping applications.
Purpose of the Study:
- To review imaging characteristics of different glioma molecular phenotypes.
- To explore the relationship between molecular phenotypes and glioma radiosensitivity and chemosensitivity.
- To provide insights into non-invasive evaluation of glioma treatment outcomes.
Main Methods:
- Literature review of glioma treatment and molecular typing over the past 20 years.
- Inclusion of the latest 2020 NCCN treatment guidelines.
- Summarization of imaging characteristics and treatment sensitivities based on molecular phenotypes.
Main Results:
- Functional MRI offers non-invasive structural and functional information for intracranial lesions.
- Molecular phenotype information combined with imaging can guide treatment and evaluate outcomes.
- Different molecular phenotypes exhibit varying sensitivities to radiotherapy and chemotherapy.
Conclusions:
- Non-invasive imaging, particularly functional MRI, is vital for glioma diagnosis and characterization.
- Integrating molecular phenotype data with imaging enhances treatment strategy and outcome prediction.
- Understanding the link between molecular subtypes and treatment response is key to personalized glioma therapy.
