Related Experiment Video

Updated: Jun 25, 2025

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

641

Neuroendocrine gut-brain signaling in obesity

Tim Gruber1, Franziska Lechner2, Jean-Philippe Krieger3

  • 1Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49506, USA; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49506, USA; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.

Trends in Endocrinology and Metabolism: TEM
|May 31, 2024
PubMed

Insights

Scientists are exploring the gut-brain axis to combat the obesity pandemic. Understanding gut-brain communication offers new hope for developing effective anti-obesity therapeutics.

Area of Science:

  • Neuroendocrinology
  • Gastroenterology
  • Metabolic Research

Background:

  • The escalating obesity pandemic has seen numerous unsuccessful therapeutic interventions.
  • The gastrointestinal (GI) tract's communication with the brain is a promising area for obesity treatment.
  • Understanding the gut-brain axis is crucial for developing new anti-obesity strategies.

Purpose of the Study:

  • To summarize recent advances in the neuroendocrine aspects of the gut-brain axis.
  • To explore novel concepts, technologies, and experiments in gut-brain communication.
  • To identify potential new therapeutic avenues for obesity.

Main Methods:

  • Review of current scientific literature on the gut-brain axis.
  • Analysis of neuroendocrine signaling pathways between the GI tract and the brain.
  • Examination of recent experimental findings and technological innovations.

Main Results:

  • Significant progress has been made in understanding gut-brain crosstalk.
  • Neuroendocrine signaling plays a key role in regulating behavior, physiology, and metabolism.
  • Novel insights are emerging from cutting-edge research and technologies.

Conclusions:

  • The gut-brain axis represents a promising frontier for anti-obesity therapeutics.
  • Continued research into gut-brain communication is essential for developing effective treatments.
  • A new era of obesity therapeutics is dawning, driven by insights into the gut-brain axis.
Keywords:
GLP1brainstemgut–brain axisobesityoxytocinvagus nerve

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