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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
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Clinical Features and Risk Factors for Drug-Induced Liver Injury: A Retrospective Study From China
Xiaojuan Ma1, Zhuo Chen1, Jingzhi An1
1Department of Clinical Pharmacy, Third Hospital of Hebei Medical University, Shijiazhuang City, China.
Clinical Therapeutics
|May 31, 2024
Summary
Drug-induced liver injury (DILI) is increasing. This study identified female sex and alcohol use as key risk factors, emphasizing the need for careful drug monitoring and patient education.
Area of Science:
- Hepatology
- Clinical Pharmacology
- Drug Safety
Background:
- Rising life expectancy and widespread use of antineoplastic, anti-infective, and cardiovascular drugs contribute to increased drug-induced liver injury (DILI).
- DILI presents a growing clinical challenge, necessitating a deeper understanding of its characteristics and risk factors.
Purpose of the Study:
- To investigate the signals, clinical characteristics, and risk factors associated with DILI.
- To analyze DILI types and identify independent risk factors for liver injury.
Main Methods:
- Retrospective analysis of 1167 DILI patients from 2019-2021 in a Chinese tertiary hospital.
- Assessment of causality using the Roussel Uclaf Causality Assessment Method.
- Comparison of DILI subtypes and logistic regression analysis to identify risk factors.
Main Results:
- Hepatocellular injury (30.08%) and biochemical abnormalities only (59.30%) were the predominant DILI types.
- Antineoplastic agents, anti-infectives, and traditional Chinese medicines were the most implicated drug categories.
- Female sex (OR=1.897) and alcohol use (OR=1.905) were identified as independent risk factors for DILI.
Conclusions:
- Most DILI cases involve mild biochemical abnormalities, with hepatocellular injury being the most common symptomatic type.
- Female patients and alcohol consumption are significant risk factors for DILI.
- Clinicians should enhance patient education on safe drug use and monitor liver function regularly, especially in high-risk individuals.
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