Recent research advances in polysaccharide-based hemostatic materials: A review

Area of Science:

• Biomaterials Science
• Medical Engineering
• Polymer Chemistry

Background:

• Massive bleeding from trauma necessitates rapid hemostatic materials.
• Current hemostats face limitations including poor biocompatibility, toxicity, and biodegradability.
• Polysaccharides exhibit superior biocompatibility and in vivo biodegradability.

Purpose of the Study:

• To review polysaccharide-based hemostatic materials.
• To explore their forms, mechanisms, and applications.
• To discuss future opportunities and challenges in polysaccharide hemostats.

Main Methods:

• Literature review of polysaccharide hemostats.
• Analysis of hemostatic mechanisms.
• Evaluation of clinical applications and future prospects.

Main Results:

• Polysaccharides like alginate (AG) and chitosan (CS) show promise as hemostatic agents.
• Their non-toxic degradation products are body-absorbable.
• Significant attention is given to polysaccharide-based materials in hemostasis.

Conclusions:

• Polysaccharides are valuable for developing advanced, biocompatible hemostatic materials.
• Further research can overcome challenges and expand applications.
• Polysaccharide hemostats represent a promising area for in vivo hemostasis.