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Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

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Related Experiment Video

Updated: Jun 24, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Strain-Programmed Adhesive Patch for Accelerated Photodynamic Wound Healing.

Seong-Jong Kim¹, Mungu Kim¹, Seung Min Yang¹

¹Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, South Korea.

Advanced Healthcare Materials

|June 1, 2024

Summary

New afterglow luminescent particles (ALPs) in hyaluronic acid patches accelerate wound healing. These innovative patches combat infection and bleeding, promoting faster recovery with enhanced collagen formation.

Keywords:

afterglow luminescence particle antibacterial effect hemostatic effect photodynamic wound healing strain‐programmed patch

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Published on: January 24, 2025

Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing Technologies

Background:

Photochemical tissue bonding offers an alternative to traditional adhesives for wound healing.
Existing methods face challenges including slow healing rates, bleeding, and susceptibility to bacterial infections.
Advanced wound care solutions are needed to address these limitations effectively.

Purpose of the Study:

To develop and evaluate novel afterglow luminescent particles (ALPs) integrated into dopamine-modified hyaluronic acid (HA-DOPA) patches.
To investigate the potential of these HA-DOPA/ALP patches for accelerated wound healing, particularly in infected and bleeding scenarios.
To assess the patches' adhesive, mechanical, and therapeutic properties for advanced wound management.

Main Methods:

Fabrication and optimization of HA-DOPA/ALP patches.
Characterization of patch properties including viscoelasticity, photoluminescence, and afterglow luminescence.
In vitro, in vivo, and ex vivo testing to evaluate biocompatibility, antibacterial effects, hemostasis, and collagen restructuring.

Main Results:

ALPs significantly enhanced the viscoelastic properties of the HA-DOPA patches.
The patches demonstrated strong and rapid adhesion, promoting singlet oxygen generation and collagen fibrillogenesis.
Confirmed biocompatibility, antibacterial activity, hemostatic capability, and effective collagen restructuring in various model tests.

Conclusions:

HA-DOPA/ALP patches represent a versatile and effective solution for accelerated wound healing.
The patches successfully address challenges of bleeding and bacterial infections in wound sites.
The strain-programmed nature and seamless detachment of the patches contribute to efficient wound recovery and residue clearance.