The Importance of Pan-Immune Inflammation Value (PIV) in Predicting Coronary Collateral Circulation in Stable...

Area of Science:

• Cardiology
• Inflammation Biomarkers
• Coronary Artery Disease

Background:

• Chronic coronary syndrome (CCS) is often associated with inadequate coronary collateral circulation (CCC).
• Identifying predictors of CCC development is crucial for managing ischemic heart disease.
• Inflammatory markers have shown potential in assessing cardiovascular risk.

Purpose of the Study:

• To investigate the correlation between the pan-immune-inflammation value (PIV) and coronary collateral circulation (CCC) in patients with CCS.
• To evaluate PIV as an independent predictor of poor CCC development.

Main Methods:

• Analysis of 663 CCS patients undergoing coronary angiography with severe stenosis (≥95%).
• Classification of patients into good CCC (Rentrop score 2-3) and poor CCC (Rentrop score 0-1) groups.
• Calculation of PIV (monocyte x platelet x neutrophil/lymphocyte count) and comparison with other inflammatory markers (NLR, CRP, CAR, SII).

Main Results:

• Patients with poor CCC exhibited significantly higher levels of NLR, CRP, CAR, SII, and PIV compared to those with good CCC (P < .001 for all).
• Multivariate analysis identified age, SII, NLR, CRP, CAR, and PIV as independent predictors of poor CCC (P < .001).
• ROC analysis showed PIV (cut-off 442.2) as a strong predictor of poor CCC (AUC = 0.808, sensitivity 76.8%, specificity 70.1%).

Conclusions:

• The pan-immune-inflammation value (PIV) is a novel and independent predictor of poor coronary collateral circulation in patients with chronic coronary syndrome.
• PIV demonstrates superior predictive performance compared to other inflammatory markers for assessing CCC development.
• These findings suggest PIV can be a valuable tool for risk stratification in CCS patients.