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Can we use PET to quantify mu opioid receptors across the monkey brain, spinal cord and peripheral organs at the same

Peter J H Scott1,2,3

  • 1Department of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA. pjhscott@umich.edu.

European Journal of Nuclear Medicine and Molecular Imaging
|June 1, 2024
PubMed
Abstract

No abstract available in PubMed .

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Opioid Receptors: Overview01:22

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Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
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