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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
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Outcomes of patients with cardiac amyloidosis undergoing percutaneous left atrial appendage occlusion
Siddharth Agarwal1, Sukriti Banthiya2, Agam Bansal3
1Department of Medicine, University of Oklahoma Health Sciences Center, 800 Stanton L. Young Blvd, AAT 5400, Oklahoma City, OK, USA.
Summary
Patients with cardiac amyloidosis undergoing left atrial appendage occlusion (LAAO) have increased peri-procedural risks. However, outcomes like bleeding and stroke-related readmissions showed no significant differences compared to other patients.
Area of Science:
- Cardiology
- Medical Devices
- Clinical Outcomes
Background:
- Limited data exists on left atrial appendage occlusion (LAAO) safety and efficacy in cardiac amyloidosis patients.
- Cardiac amyloidosis is an understudied condition in the context of LAAO procedures.
Purpose of the Study:
- To evaluate the safety and efficacy of LAAO devices in patients with cardiac amyloidosis.
- To compare outcomes of LAAO in cardiac amyloidosis patients versus those without.
Main Methods:
- Analysis of the National Readmissions Database (NRD) from 2016-2019.
- Inclusion of patients aged 18+ with atrial fibrillation undergoing LAAO.
- Multivariable logistic regression to assess cardiac amyloidosis association with outcomes.
Main Results:
- A cohort of 54,900 LAAO procedures included 220 (0.4%) with cardiac amyloidosis.
- Cardiac amyloidosis patients had higher odds of peri-procedural major adverse events (aOR: 2.69) and neurological complications (aOR: 5.48).
- No significant differences were observed in other complications, mortality, resource utilization, or 30/90/180-day readmissions.
Conclusions:
- Cardiac amyloidosis patients undergoing LAAO face increased peri-procedural complication risks.
- No significant differences in bleeding or stroke-related readmissions were found.
- Findings suggest a need for further prospective validation.
