Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparison of drug dosing methods.

M E Burton, M R Vasko, D C Brater

    Clinical Pharmacokinetics
    |January 1, 1985
    PubMed
    Summary

    Accurate drug dosing is crucial for patient response, especially for narrow therapeutic index drugs. Bayesian feedback and individualized methods using serum drug concentrations offer the most precise dosing strategies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Defining hypercalciuria in nephrolithiasis.

    Kidney international·2011
    Same author

    Ras signaling pathways mediate NGF-induced enhancement of excitability of small-diameter capsaicin-sensitive sensory neurons from wildtype but not Nf1+/- mice.

    Neuroscience letters·2011
    Same author

    Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel.

    Neurotoxicology·2010
    Same author

    Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons.

    Neuroscience·2010
    Same author

    Drug dosing in patients with impaired renal function.

    Clinical pharmacology and therapeutics·2009
    Same author

    Factors associated with exacerbation of heart failure include treatment adherence and health literacy skills.

    Clinical pharmacology and therapeutics·2009

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Drug Monitoring

    Background:

    • Drug dosing often shows poor correlation with serum drug concentrations and clinical response.
    • Serum drug concentrations correlate better with clinical response, leading to their use in dose adjustments.
    • Narrow therapeutic index drugs require precise dosing to maximize efficacy and minimize toxicity.

    Purpose of the Study:

    • To review and evaluate commonly used drug dosing methods.
    • To assess the accuracy and precision of different dosing strategies in achieving target serum drug concentrations.
    • To compare the effectiveness of various methods for drugs with narrow therapeutic ranges.

    Main Methods:

    • Literature review of drug dosing methods.
    • Evaluation of standard doses, population-based algorithms, nomograms, pharmacokinetic equations, and Bayesian feedback.
    • Focus on five drugs: gentamicin, digoxin, phenytoin, theophylline, and lignocaine (lidocaine).

    Main Results:

    • Individualized and Bayesian methods using serum drug concentration feedback demonstrate superior accuracy and precision.
    • The Bayesian method offers greater flexibility, accommodating varying numbers of serum drug concentration measurements.
    • Standard doses and some predictive algorithms show less reliable outcomes.

    Conclusions:

    • Bayesian and individualized dosing methods are most effective for achieving desired serum drug concentrations and clinical response.
    • Further research is needed to establish the cost-effectiveness of these advanced dosing methods in routine patient care.
    • Optimizing drug dosing through therapeutic drug monitoring is essential for improving patient outcomes.

    Related Experiment Videos