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Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Cyclodextrin-based metal-organic frameworks transforming drug delivery.

Na Yang1, Lingling Wei1, Yuou Teng1

  • 1China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, 300457, Tianjin, China.

European Journal of Medicinal Chemistry
|June 1, 2024
PubMed
Summary

Cyclodextrin-based metal-organic frameworks (CD-MOFs) offer enhanced drug delivery by improving loading, stability, and bioavailability. Customization enables controlled and targeted release, showcasing their versatility for biomedical applications.

Keywords:
ContentsControl/targeted releaseCyclodextrinsDrug deliveryMetal organic framework

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Synthesis and Characterization of Functionalized Metal-organic Frameworks
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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Cyclodextrin-based metal-organic frameworks (CD-MOFs) are emerging as promising materials for advanced drug delivery systems.
  • Their unique structure and properties offer significant potential to improve therapeutic outcomes.

Purpose of the Study:

  • To explore the preparation techniques of CD-MOFs.
  • To highlight the advantages of native and modified CD-MOFs in drug delivery applications.
  • To discuss strategies for controlled and targeted drug release using CD-MOFs.

Main Methods:

  • Overview of predominant CD-MOF preparation methods: vapor diffusion, microwave-assisted, and ultrasound hydrothermal synthesis.
  • Discussion of drug interaction mechanisms within CD-MOFs (host-guest, hydrogen bonding, electrostatic interactions).
  • Analysis of customization strategies: co-crystallization and surface post-modification for tailored drug carriers.

Main Results:

  • Native CD-MOFs enhance drug loading capacity, stability, solubility, and bioavailability.
  • Customized CD-MOFs facilitate controlled release profiles (sustained and responsive to stimuli like pH, glutathione, cations).
  • CD-MOFs enable targeted delivery strategies, improving precision in applications like pulmonary delivery.

Conclusions:

  • CD-MOFs represent a versatile platform for drug delivery, offering tunable properties for enhanced efficacy and safety.
  • Tailored modifications of CD-MOFs provide solutions for controlled and targeted therapeutic interventions.
  • The adaptability of CD-MOFs addresses diverse biomedical and industrial needs in drug delivery.