Related Experiment Video

Updated: Jun 24, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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Extra-nuclear and cytoplasmic steroid receptor signalling in hormone dependent cancers

Stephanie Agbana1, Marie McIlroy1

  • 1Androgens in Health and Disease research group, RCSI University of Medicine and Health Sciences, Dublin, Ireland; Department of Surgery, RCSI University of Medicine and Health Sciences, Ireland.

The Journal of Steroid Biochemistry and Molecular Biology
|June 1, 2024
PubMed

Insights

Steroid hormones act through genomic and non-genomic pathways. This review highlights recent advances in non-genomic steroid action and receptor biology, crucial for understanding endocrine cancers.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Steroid hormone receptors mediate hormone action via genomic and non-genomic pathways.
  • Genomic understanding has advanced with omics research, but non-genomic actions are also critical.
  • Steroid hormone actions are simultaneous and reciprocal, requiring a holistic cell-based evaluation.

Purpose of the Study:

  • To review recent developments in non-genomic steroid action.
  • To discuss cytoplasmic steroid hormone receptor biology in endocrine cancers.
  • To focus on 3-keto steroid receptors, especially the androgen receptor.

Main Methods:

  • Literature review of recent scientific publications.
  • Focus on omics-based research and non-genomic signaling pathways.
  • Analysis of cytoplasmic steroid hormone receptor roles.

Main Results:

  • Steroid hormones exhibit rapid non-genomic signaling alongside genomic effects.
  • Cytoplasmic receptor activity plays a significant role in endocrine-related cancers.
  • Androgen receptor (AR) is a key focus within 3-keto steroid receptors.

Conclusions:

  • A comprehensive understanding of both genomic and non-genomic steroid actions is essential.
  • Non-genomic actions and cytoplasmic receptor dynamics are vital in endocrine cancer biology.
  • Further research into these mechanisms, particularly AR, is needed for therapeutic strategies.
Keywords:
Endocrine-related cancerLigandsNon-canonical/ non-genomicSteroid receptors

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