Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Δnp63-restricted Viral Mimicry Response Impedes Cancer Cell Viability And Remodels Tumor Microenvironment In Esophageal Squamous Cell Carcinoma.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Δnp63-restricted Viral Mimicry Response Impedes Cancer Cell Viability And Remodels Tumor Microenvironment In Esophageal Squamous Cell Carcinoma.

Related Experiment Video

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.3K

ΔNp63-restricted viral mimicry response impedes cancer cell viability and remodels tumor microenvironment in esophageal squamous cell carcinoma.

Valen Zhuoyou Yu1, Shan Shan So1, Bryan Chee-Chad Lung1

  • 1Department of Clinical Oncology, Centre of Cancer Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

Cancer Letters
|June 1, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Tumor protein p63 isoform ΔNp63 drives esophageal squamous cell carcinoma (ESCC) by suppressing antiviral defenses. Targeting ΔNp63 may enhance cancer treatments and improve immune responses in ESCC patients.

More Related Videos

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.5K
Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.5K

Related Experiment Videos

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.3K
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.5K
Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.5K

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Tumor protein p63 isoform ΔNp63 is implicated in squamous epithelium and squamous cell carcinomas (SCCs), including esophageal SCC (ESCC).
  • Understanding the precise oncogenic mechanisms of ΔNp63 in ESCC is crucial for developing targeted therapies.

Purpose of the Study:

  • To elucidate the novel oncogenic role of ΔNp63 in ESCC.
  • To investigate the impact of ΔNp63 on cancer cell intrinsic pathways and the tumor microenvironment.
  • To assess the therapeutic potential of targeting ΔNp63 in ESCC.

Main Methods:

  • Integrated analysis of data from cell lines, patient-derived organoid cultures, and xenograft models.
  • Transcriptomic analyses of clinical ESCC and lung SCC samples.
  • Investigation of the ΔNp63/IFN-I signaling axis and its regulation of retrotransposon expression, dsRNA sensing, and immune cell infiltration.

    • Main Results:

    • ΔNp63 maintains repression of endogenous retrotransposons and dsRNA sensing, restricting viral mimicry and suppressing type I interferon (IFN-I) signaling.
    • Depletion of ΔNp63 reduces cancer cell viability and enhances responses to viral mimicry boosters.
    • ΔNp63 expression negatively correlates with tumor-infiltrating immune cell (TIIC) signatures and antigen presentation in ESCC and lung SCC.

    Conclusions:

    • ΔNp63 plays a robust oncogenic role in ESCC by modulating cancer cell intrinsic immunity and the tumor microenvironment.
    • The ΔNp63/IFN-I signaling axis represents a potential therapeutic target and biomarker for guiding anticancer treatments in SCCs.
    • Targeting ΔNp63 may enhance immune cell recruitment and reprogramming, improving therapeutic outcomes.