Related Experiment Video
Updated: May 3, 2026

21:16
An In Vitro Skin Irritation Test SIT using the EpiDerm Reconstructed Human Epidermal RHE Model
Published on: July 13, 2009
67.8K
[Translated article] Standard and Expanded Series Patch Testing Update by the Spanish Contact Dermatitis and Skin
F J Navarro-Triviño1, L Borrego2, J F Silvestre-Salvador3
1Servicio de Dermatología, Hospital Universitario San Cecilio, Granada, Spain.
Actas Dermo-Sifiliograficas
|June 1, 2024
Summary
The Spanish Standard Series patch testing was updated in 2022, adding new allergens like hydroxyethyl methacrylate and textile dye mix. Ethyldiamine and phenoxyethanol were removed to improve diagnostic accuracy for allergic contact dermatitis.
Area of Science:
- Dermatology
- Allergology
- Contact Dermatitis Research
Background:
- The Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) periodically reviews and updates standard patch test series.
- Previous standard series were established in 2016, necessitating updates based on evolving allergen prevalence and diagnostic needs.
Purpose of the Study:
- To detail the modifications made to the Spanish Standard Series patch testing.
- To inform dermatologists and allergists about the updated allergen composition for improved diagnosis of allergic contact dermatitis.
Main Methods:
- A meeting of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) in October 2021 proposed changes.
- Specific allergens were added or excluded from the standard series based on expert consensus and epidemiological data.
Main Results:
- The 2022 Spanish Standard Series includes newly added allergens: hydroxyethyl methacrylate (2% pet.), textile dye mixture (6.6% pet.), linalool hydroperoxide (1% pet.), and limonene hydroperoxide (0.3% pet.).
- Ethyldiamine and phenoxyethanol have been excluded from the updated series.
- Additional allergens incorporated into the extended 2022 series include methyldibromoglutaronitrile, sesquiterpene lactone mixture, and hydroxyisohexyl 3-cyclohexene (Lyral).
Conclusions:
- The updated Spanish Standard Series patch testing aims to enhance the diagnostic capabilities for allergic contact dermatitis.
- These revisions reflect current trends in allergen exposure and sensitization, ensuring more relevant testing for patients.

