Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spin-orbit-resolved strong-field ionization from real-time relativistic dynamics.

The Journal of chemical physics·2026

Same author

Adult intussusception caused by solitary intestinal Peutz-Jeghers polyp mimicking a malignant colon cancer.

Journal of surgical case reports·2026

Same author

Long-Range Order in a Strictly Short-Range Quasi-2D XY Model: When Critical Fluctuations Matter.

Physical review letters·2026

Same author

Multifunctional nanotherapeutics for tumor microenvironment modulation in solid tumor therapy.

Discover nano·2026

Same author

ctDNA-guided precision therapy with trastuzumab deruxtecan plus pyrotinib in HER2-positive breast cancer brain metastases: a case report.

Frontiers in oncology·2026

Same author

DMN-YOLO: A Lightweight Small-Object Detector for Multi-Species Animal Detection in UAV Grassland Imagery.

Animals : an open access journal from MDPI·2026

Same journal

Salt priming coordinates transcriptional and epigenetic states for enhanced salt tolerance in mung bean (Vigna radiata).

Communications biology·2026

Same journal

A male-derived volatile sex pheromone in Caenorhabditis nematodes identified through its mimicry by a predator.

Communications biology·2026

Same journal

Revalidation of Manis aurita based on integrative genomic and morphological evidence.

Communications biology·2026

Same journal

Presenilin-1 controls glycolysis and identity of pancreatic beta cells.

Communications biology·2026

Same journal

Base editing-derived models of human WDR34 and WDR60 disease alleles replicate retrograde intraflagellar transport (IFT) and hedgehog signaling defects.

Communications biology·2026

Same journal

Butterflies with low thermoregulatory capacity show greatest upwards range shifts along an elevational gradient.

Communications biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 3, 2026

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing

Published on: June 9, 2016

Accelerating 3D genomics data analysis with Microcket.

Yu Zhao¹, Mengqi Yang^2,3, Fanglei Gong²

¹Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China.

Communications Biology

|June 1, 2024

Summary

This summary is machine-generated.

Microcket is a new bioinformatics package that efficiently analyzes three-dimensional (3D) genome sequencing data. This tool speeds up the study of genome organization, making complex biological investigations more accessible.

More Related Videos

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Published on: November 3, 2023

Related Experiment Videos

Last Updated: May 3, 2026

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing

Published on: June 9, 2016

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Published on: November 3, 2023

Area of Science:

Genomics
Molecular Biology
Bioinformatics

Background:

The three-dimensional (3D) genome organization is crucial for cellular functions.
High-throughput sequencing methods generate vast amounts of data for 3D genome analysis.
Current analysis tools are often time-consuming and computationally intensive.

Purpose of the Study:

To introduce Microcket, a novel software package for analyzing 3D genomics data.
To provide a faster and more efficient method for mapping and extracting interacting DNA pairs from 3D genome datasets.
To improve the analysis of Hi-C, Micro-C, and related genomic interaction data.

Main Methods:

Development of Microcket, a bioinformatics package utilizing a unique read-stitch strategy.
Leveraging long read cycles from modern DNA sequencers for enhanced data processing.
Benchmarking Microcket against existing tools for speed and mapping efficiency.

Main Results:

Microcket demonstrates significantly faster processing speeds compared to current tools.
The package achieves improved mapping efficiency for 3D genomics data.
Benchmark evaluations confirm the performance advantages of Microcket.

Conclusions:

Microcket offers a substantial improvement in the analysis of 3D genome data.
The tool's speed and efficiency have high potential to accelerate biological research into genome organization.
Microcket is freely available, promoting wider accessibility for 3D genomics studies.