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Related Concept Videos

Caspases01:24

Caspases

12.4K
Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Updated: Jun 24, 2025

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila
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In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

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Exploring caspase functions in mouse models.

Eva Svandova1, Barbora Vesela2, Eva Janeckova3

  • 1Laboratory of Odontogenesis and Osteogenesis, Institute of Animal Physiology and Genetic, Brno, Czech Republic. evabsvandova@gmail.com.

Apoptosis : an International Journal on Programmed Cell Death
|June 2, 2024
PubMed
Summary
This summary is machine-generated.

Caspase enzymes, initially linked to cell death, are now known to regulate cell proliferation and differentiation. Caspase knock-out mice are crucial for understanding their complex roles in diseases like cancer.

Keywords:
Animal modelApoptoticCaspasesDeficiencyMouseNon-apoptoic

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Caspases are proteases known for over 30 years.
  • Initially linked to apoptosis and inflammation.
  • Emerging roles in cell proliferation, migration, and differentiation.

Purpose of the Study:

  • To summarize recent knowledge on caspases.
  • To discuss understanding and challenges of caspase knock-out mice.
  • To highlight caspases as therapeutic targets for various diseases.

Main Methods:

  • Review of in vitro studies.
  • Analysis of data from caspase knock-out mouse models.
  • Discussion of the complexity of in vivo systems.

Main Results:

  • Caspase functions extend beyond cell death.
  • Caspases are implicated in diverse pathological conditions.
  • Knock-out mouse models are essential for in vivo validation.

Conclusions:

  • Caspase research continues to reveal novel functions.
  • Caspases are promising therapeutic targets for inflammatory, neurological, metabolic, and oncological diseases.
  • Further research using caspase knock-out mice is needed to fully elucidate their roles and therapeutic potential.