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Published on: March 7, 2013
Cognitive function of children with biliary atresia after primary living donor liver transplantation
Tingge Wang1, Yan Hu1, Zhanzhan Zhang1
1Department of Child Health Care, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China.
Insights
Children with biliary atresia (BA) who underwent liver transplantation (LT) show developmental delays. Reoperation and nutritional issues negatively impact cognitive development in these young patients.
Area of Science:
- Pediatric Gastroenterology
- Hepatology
- Developmental Pediatrics
Background:
- Biliary atresia (BA) survival rates improve post-liver transplantation (LT), increasing focus on quality of life.
- Investigating cognitive development in infants with BA post-primary living donor LT (BA-pLDLT) is crucial.
Purpose of the Study:
- To assess cognitive development in children with BA after BA-pLDLT.
- To identify factors influencing cognitive function in this population.
Main Methods:
- Recruited 57 children with BA 6 months post-pLDLT.
- Collected demographic and clinical data; assessed cognition using the Griffiths Mental Development Scale (GMDS-C).
- Employed multivariate linear regression to analyze influencing factors.
Main Results:
- Children with BA-pLDLT exhibited significantly lower general developmental quotients and specific domain quotients (motor, language, etc.) compared to GMDS-C norms.
- 28.07% had borderline developmental delay, 5.26% had developmental delay, and 19.29% had language delay.
- Reoperation for complications was a risk factor for decreased general and motor quotients; lower ZW correlated with motor quotient decline.
Conclusions:
- Children with BA-pLDLT experience developmental delays in early life.
- Reoperation and nutritional deficiencies adversely affect cognitive development in these children.
Background:
The survival rate of children with biliary atresia (BA) after liver transplantation (LT) is significantly improved, and their quality of life has attracted much attention.This study aimed to investigate the cognition and its influencing factors in children with BA after primary living donor LT (BA-pLDLT) during infancy.
Methods:
Children with BA were recruited 6 months after pLDLT at Children's Hospital of Chongqing Medical University (2018-2022). Demographic and clinical data were collected from the health information system. Cognition was assessed using the Chinese version of the Griffiths Mental Development scale (GMDS-C). Multivariate linear regression were used to analyze the influencing factors of their cognitive function.
Results:
In total, 57 children with BA-pLDLT, aged 5.00(3.90-9.30) months at transplantation and 25.00(14.00-60.80) months at evaluation were included. The general developmental quotient (89.02 ± 12.07) and motor, language, eye-hand coordination, performance, and practical reasoning quotients of these children were significantly lower than the normative mean values of GMDS-C(P < 0.05). Of the 57 children, 16 (28.07%) had borderline developmental delay (DQ between 70 and 84), 3 (5.26%) had developmental delay (DQ < 70), and 11(19.29%) had language delay. Reoperation for biliary or vascular complications after pLDLT was a risk factor for decreased general development quotient and motor quotient and lower ZW at assessment was associated with decline motor quotient.
Conclusion:
Children with BA-pLDLT have varying degrees of developmental delays in early life. Reoperation and nutritional deficiencies had adverse effects on cognitive development.
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