High stress hyperglycemia ratio predicts adverse clinical outcome in patients with coronary three-vessel disease: a
Zheng Qiao1,2, Xiaohui Bian1,2, Chenxi Song1,2
1State Key Laboratory of Cardiovascular Disease, Beijing, China.
Cardiovascular Diabetology
|June 2, 2024
Summary
High stress hyperglycemia ratio (SHR) predicts adverse cardiovascular events in coronary three-vessel disease patients undergoing percutaneous coronary intervention, regardless of diabetes status. This finding aids in risk stratification for these high-risk patients.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Clinical Research
Background:
- Coronary three-vessel disease (CTVD) presents a significant risk for cardiovascular events.
- Dysregulated glucose metabolism is linked to atherosclerosis and increased cardiovascular risk.
- The stress hyperglycemia ratio (SHR) may indicate glucose metabolism status, but its prognostic value in CTVD patients undergoing PCI is not well-established.
Purpose of the Study:
- To investigate the association between SHR and long-term cardiovascular outcomes in patients with CTVD undergoing percutaneous coronary intervention (PCI).
- To determine if SHR can improve risk stratification in this patient population.
Main Methods:
- A cohort of 10,532 CTVD patients undergoing PCI was analyzed.
- SHR was calculated using admission blood glucose and HbA1c levels.
- Multivariable Cox regression models assessed the relationship between SHR and cardiovascular events (cardiac death, non-fatal myocardial infarction) over a median 3-year follow-up.
Main Results:
- High SHR was significantly associated with a higher risk of cardiovascular events (HR 1.99, P < 0.001).
- This association persisted in patients with and without diabetes.
- Incorporating SHR into risk models significantly improved predictive capabilities.
Conclusions:
- SHR is a significant predictor of adverse cardiovascular outcomes in CTVD patients undergoing PCI.
- SHR aids in risk stratification, irrespective of diabetes status or underlying glucose metabolism.
- The findings highlight the utility of SHR in managing high-risk cardiovascular patients.
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