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Post-epileptic seizure posttraumatic stress Disorder: A mediation analysis
Deniz Ertan1, Nicolas Mezouar2, Alexis Tarrada3
1Institut La Teppe Tain l'Hermitage, France; CHRU de Nancy, Département de Neurologie, Nancy, France.
Epilepsy & Behavior : E&B
|June 2, 2024
Summary
Post-epileptic seizure posttraumatic stress disorder (PS-PTSD) is linked to higher depression and anxiety in people with epilepsy (PWE). Past trauma and ictal anxiety significantly influence PS-PTSD through interictal mood symptoms.
Area of Science:
- Neurology
- Psychiatry
- Trauma Studies
Background:
- Post-epileptic seizure posttraumatic stress disorder (PS-PTSD) prevalence varies.
- Understanding factors contributing to PS-PTSD in people with epilepsy (PWE) is crucial.
Purpose of the Study:
- Compare profiles of PWE with and without PS-PTSD.
- Investigate interactions between past trauma, ictal anxiety, comorbidities, and PS-PTSD in PWE.
Main Methods:
- Observational study using standardized scales (CTQ-28, LEC-5, PCL-5) for trauma and PS-PTSD.
- Semi-structured interviews and validated scales (NDDIE, GAD-7) for psychiatric comorbidities.
- Mediation analysis to assess the influence of past trauma and ictal anxiety on PS-PTSD via interictal depression and anxiety.
Main Results:
- 135 PWE studied; 29.5% had PS-PTSD.
- PS-PTSD group showed higher depression and anxiety scores and more peri-ictal symptoms.
- Past trauma's link to PS-PTSD was mediated by interictal depression and anxiety; ictal anxiety indirectly affected PS-PTSD.
Conclusions:
- PWE with PS-PTSD exhibit a more severe psychopathological profile.
- Interictal and subjective ictal anxiety play significant roles in PS-PTSD development and maintenance.
