Related Experiment Video

Updated: Jun 24, 2025

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
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Advances in immune regulation of the G protein-coupled estrogen receptor

Hanzhi Dong1, Xiaoqiang Zeng2, Jiawei Xu3

  • 1Department of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, China.

International Immunopharmacology
|June 2, 2024
PubMed

Insights

The G protein-coupled estrogen receptor (GPER) is a key player in immune regulation and diseases. Targeting GPER offers potential for novel cancer immunotherapies and treatments for immune-related conditions.

Area of Science:

  • Endocrinology
  • Immunology
  • Oncology

Background:

  • Estrogen receptors (ERs) influence development, reproduction, metabolism, and immunity.
  • Nuclear ERs (ERα, ERβ) were traditionally recognized; G protein-coupled estrogen receptor (GPER) is now identified as a third independent ER.
  • GPER-mediated estrogen signaling is crucial in physiology and various diseases.

Purpose of the Study:

  • To review current advancements in GPER-related immunomodulators.
  • To provide a theoretical foundation for targeting GPER in immune diseases and cancer immunotherapy.
  • To identify potential clinical targets for GPER-based therapies.

Main Methods:

  • Literature review of studies on GPER and immunomodulation.
  • Analysis of GPER's role in immune system maintenance and disease.
  • Exploration of GPER's implications in tumor immunotherapy.

Main Results:

  • GPER is increasingly recognized for its role in immune system regulation.
  • GPER involvement is noted in abnormal immune diseases and inflammatory lesions.
  • GPER modulation shows promise for cancer immunotherapy.

Conclusions:

  • GPER is a significant target for modulating immune responses.
  • GPER-based strategies may offer new avenues for treating immune-related diseases.
  • Targeting GPER holds potential for enhancing cancer immunotherapy efficacy.
Keywords:
EstrogenGPERImmunomodulatorsImmunotherapy

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