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Regulation of Nuclear Protein Sorting

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...

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Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
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Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Published on: December 3, 2015

Nucleic acid-responsive smart systems for controlled cargo delivery.

Akbar Hasanzadeh¹, Arefeh Ebadati², Sara Saeedi³

¹Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

Biotechnology Advances

|June 2, 2024

Summary

This summary is machine-generated.

Nucleic acid-responsive delivery systems offer controlled cargo transport. This review covers DNA/RNA, aptamer, and CRISPR-responsive systems, detailing their benefits and drawbacks for targeted delivery.

Keywords:

Aptamer targeting CRISPR-responsive Controlled release NA-responsive Smart delivery vehicle

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Area of Science:

Biomaterials Science
Nanotechnology
Molecular Biology

Background:

Stimulus-responsive delivery systems enable precise cargo transport, minimizing adverse effects.
Nucleic acids (NAs) possess unique structural and functional properties, making them suitable for advanced molecular applications.
Nucleic acid-responsive intelligent delivery vehicles are an emerging area with programmable and reversible characteristics.

Purpose of the Study:

To review various types of nucleic acid-responsive controlled delivery vehicles.
To summarize the advantages and limitations of these systems.
To provide insights into the design and application of NA-responsive delivery systems.

Main Methods:

Literature review of nucleic acid-responsive delivery systems.
Categorization of systems based on NA-responsive mechanisms (lock and key principle).
Analysis of DNA/RNA-responsive, aptamer-responsive, and CRISPR-responsive systems.

Main Results:

Identified several classes of NA-responsive delivery vehicles.
Detailed the mechanisms, advantages, and limitations of each system type.
Highlighted the programmability, controllability, and reversibility of these intelligent vehicles.

Conclusions:

Nucleic acid-responsive delivery systems represent a promising frontier in targeted therapeutics and diagnostics.
Understanding the specific advantages and limitations of each NA-responsive mechanism is crucial for optimal system design.
Further research into these systems will likely lead to more sophisticated and efficient drug delivery solutions.