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Updated: Jun 24, 2025

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
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Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Published on: April 26, 2024

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Transcriptional regulation of Tfh dynamics and the formation of immunological synapses

Ye-Ji Kim1, Jinyong Choi2, Youn Soo Choi3,4,5

  • 1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.

Experimental & Molecular Medicine
|June 2, 2024
PubMed

Inside germinal centers (GCs), antigen-specific B cells rely on precise interactions with immune cells and strategic localization between the dark and light zones to clonally expand, undergo affinity maturation, and differentiate into long-lived plasma cells or memory B cells. Follicular helper T (Tfh) cells, the key gatekeepers of GC-dependent humoral immunity, exhibit remarkable dynamic positioning within secondary lymphoid tissues and rely on intercellular interactions with antigen-presenting cells (APCs) during their differentiation and execution of B-cell-facilitating functions within GCs. In this review, we briefly cover the transcriptional regulation of Tfh cell differentiation and function and explore the molecular mechanisms governing Tfh cell motility, their interactions with B cells within GCs, and the impact of their dynamic behavior on humoral responses.

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