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Time With Rapid Change of Glucose
Mia Christensen1, Louise Jung Nørgaard1, Mette Bohl1,2
1Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark.
Journal of Diabetes Science and Technology
|June 3, 2024
Summary
A new metric, time with rapid change of glucose (TRC), offers an understandable way to assess glycemic variability. This metric correlates with existing measures and aids in evaluating closed-loop insulin systems for better glucose control.
Area of Science:
- Endocrinology
- Biomedical Engineering
- Diabetes Technology
Background:
- Existing glycemic variation metrics can be complex to interpret.
- There is a need for simpler, more intuitive measures of glucose control.
Purpose of the Study:
- To introduce and define a novel metric: time with rapid change of glucose (TRC).
- To evaluate TRC's correlation with established glucose variability metrics.
- To propose TRC as a tool for assessing automated insulin delivery systems.
Main Methods:
- Analyzed 90-day continuous glucose monitoring data from 159 individuals with type 1 diabetes.
- Defined TRC as the percentage of time with an absolute glucose change rate exceeding 1.5 mmol/L/15 minutes within a specific glucose range.
- Calculated TRC and compared it with within-day coefficient of variation (CVw) and mean amplitude of glycemic excursion (MAGE).
Main Results:
- The median TRC was 6.9%, with a significantly higher proportion of rapid increases (3.9%) compared to decreases (2.8%).
- TRC demonstrated strong correlations with CVw (Spearman's ρ = 0.56) and MAGE (Spearman's ρ = 0.65).
- Over 1.27 million glucose rate changes were analyzed.
Conclusions:
- TRC is a readily understandable metric for quantifying glycemic variability.
- TRC shows promise for comparing the efficacy of automated insulin delivery systems in achieving glucose homeostasis.
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