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Updated: Jun 24, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Published on: June 6, 2017
The Cell Cycle: a Key to Unlock EZH2-targeted Therapy Resistance
Rachel L Paolini1,2, George P Souroullas1,2,3
1Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Summary:
In this issue, a study by Kazansky and colleagues explored resistance mechanisms after EZH2 inhibition in malignant rhabdoid tumors (MRT) and epithelioid sarcomas (ES). The study identified genetic alterations in EZH2 itself, along with alterations that converge on RB1-E2F-mediated cell-cycle control, and demonstrated that inhibition of cell-cycle kinases, such as Aurora Kinase B (AURKB) could bypass EZH2 inhibitor resistance to enhance treatment efficacy. See related article by Kazansky et al., p. 965 (6).
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