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Updated: Jun 24, 2025
06:41
Assessment of Social Interaction Behaviors
Published on: February 25, 2011
93.2K
Shared genetics linking sociability with the brain's default mode network.
Giuseppe Fanelli1,2, Jamie Robinson3, Chiara Fabbri1
1Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Medrxiv : the Preprint Server for Health Sciences
|June 3, 2024
Summary
This study reveals genetic links between sociability and brain
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- The brain's default mode network (DMN) is crucial for social cognition.
- Altered DMN function is linked to social impairments in neuropsychiatric disorders.
Purpose of the Study:
- To investigate the genetic relationship between sociability and DMN-related resting-state functional magnetic resonance imaging (rs-fMRI) traits.
- To identify genes influencing both sociability and DMN function.
Main Methods:
- Genome-wide association summary statistics for sociability and DMN rs-fMRI traits were analyzed.
- Genetic correlations and bi-directional Mendelian randomization (MR) were performed.
- Gene prioritization combined eQTL MR, CELLECT framework, and network propagation.
Main Results:
- Significant local genetic correlations were found between sociability and DMN activity/connectivity traits.
- Sociability influenced 12 rs-fMRI traits.
- Seventeen genes were prioritized, with DRD2 and LINGO1 showing strong evidence.
Conclusions:
- Genetic factors link sociability to specific DMN functional traits.
- Prioritized genes like DRD2 and LINGO1 may be biomarkers for social dysfunction and potential drug targets.
- Integrated genetic and transcriptomic data offer a strategy for future research.
Keywords:
brain activitybrain connectivityexpression quantitative trait loci (eQTL)imaging geneticsneuroimagingsocial withdrawalMore Related Videos
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