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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Updated: Jun 24, 2025

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes.

Hannah L Thirman^1,2,3,4, Madeline J Hayes^1,2,3, Lauren E Brown⁵

¹Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.

Biorxiv : the Preprint Server for Biology

|June 3, 2024

Summary

This summary is machine-generated.

Researchers identified specific rocaglate compounds that selectively trigger DNA damage responses in leukemia cells but not healthy cells. This discovery highlights potential new cancer therapies targeting malignant cells with minimal side effects.

Keywords:

Rocaglates cancer cell signaling chemical biology cytometry phospho-flow

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Last Updated: Jun 24, 2025

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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Published on: October 25, 2018

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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

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Published on: October 19, 2014

Area of Science:

Chemical biology
Molecular pharmacology
Cellular signaling

Background:

Distinguishing molecular families with structure-activity relationships is crucial for developing cell-selective therapies.
Small structural changes in molecules can lead to significant differences in cellular responses and bioactivity across cell types.

Conclusions:

The rocaglate pyrimidinone (RP) subclass shows significant potential for anticancer therapeutic development targeting the DNA damage response pathway.
Single-cell profiling effectively dissects how structural variations in chemicals differentially impact healthy and diseased cells.
This approach provides a platform for discovering cell-selective chemical effectors.