Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

Overview of Lipid Metabolism

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

Hepatic Drug Excretion: Enterohepatic Cycling

Hepatic Drug Excretion: Enterohepatic Cycling

Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

Diseases of the Liver and Gallbladder

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

Lipids: Dietary Sources and Requirements

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Endoscopic Ultrasound With Fine Needle Biopsy Confirming a Diagnosis of Immune Checkpoint Inhibitor-Related Type 3 Autoimmune Pancreatitis.

Case reports in gastrointestinal medicine·2025

Same author

Proton density fat fraction for diagnosis of metabolic dysfunction-associated steatotic liver disease.

Hepatology (Baltimore, Md.)·2025

Same author

The potential role of infusions of T regulatory cells in inducing and maintaining liver allograft tolerance.

Clinical liver disease·2023

Same author

Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis.

PloS one·2021

Same author

Metaanalysis Reveals Genetic Correlates of Osteoporosis Pathogenesis.

The Journal of rheumatology·2020

Search research articles

Related Experiment Video

Updated: Jun 24, 2025

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Cholestasis Linked to Bodybuilding Supplements: Exploring the Risks of Contamination.

Mark Matusak¹, Jihad Aljabban², Mark Wirtz¹

¹Department of Family Medicine, University of Wisconsin Hospital and Clinics, Madison, USA.

Case Reports in Hepatology

|June 3, 2024

Summary

This summary is machine-generated.

Bodybuilding supplements can cause drug-induced liver injury, often due to unlabeled anabolic-androgenic steroids. Healthcare providers should screen for supplement use to identify and manage this condition.

More Related Videos

Creation of Reversible Cholestatic Rat Model

Creation of Reversible Cholestatic Rat Model

Published on: May 21, 2011

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Published on: January 12, 2020

Related Experiment Videos

Last Updated: Jun 24, 2025

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Creation of Reversible Cholestatic Rat Model

Creation of Reversible Cholestatic Rat Model

Published on: May 21, 2011

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Published on: January 12, 2020

Area of Science:

Hepatology
Sports Medicine
Toxicology

Background:

Drug-induced liver injury (DILI) from herbal and dietary supplements is a growing concern.
Anabolic-androgenic steroids (AAS) are frequently misused in bodybuilding for performance enhancement.

Observation:

A 34-year-old male bodybuilder presented with symptoms including fatigue, itching, and muscle cramps.
Laboratory tests revealed cholestatic liver injury, and liver biopsy showed bland cholestasis and sinusoidal dilation.

Findings:

The patient was diagnosed with anabolic-androgenic steroid-induced liver injury (AAS-DILI).
Symptomatic treatment included plasmapheresis for severe itching (pruritus).

Implications:

This case underscores the risk of DILI from bodybuilding supplements containing undeclared AAS.
Clinicians should actively inquire about supplement use and remain vigilant for potential liver injury complications.