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The Relationship Between Changes of Left Heart Structure and Function and the Risk of Future Renal Damage in Patients

Fei Li1, Feifei Yan2, Shengnan Liu1

  • 1Department of Cardiovascular Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430000, People's Republic of China.

International Journal of General Medicine
|June 3, 2024
PubMed

Insights

Cardiac remodeling indicators like left ventricular ejection fraction (LVEF) and interventricular septum thickness (IVST) can predict future kidney damage in hypertension. A simplified risk score effectively assesses early-stage renal impairment risk.

Area of Science:

  • Cardiology
  • Nephrology
  • Hypertension Research

Background:

  • Cardiac remodeling in essential hypertension is linked to future renal damage.
  • Estimated glomerular filtration rate (eGFR) reflects kidney function and potential damage.

Purpose of the Study:

  • To evaluate cardiac remodeling, assessed via echocardiography, for predicting future renal damage risk in hypertensive patients.
  • To identify echocardiographic predictors of renal impairment in essential hypertension.

Main Methods:

  • Retrospective analysis of 510 hypertensive patients diagnosed between 2016-2022.
  • Utilized demography, clinical data, blood samples, and echocardiographic variables.
  • Employed survival analysis and Cox proportional hazards regression model.

Main Results:

  • Age, serum creatinine (SCR), creatine kinase isoenzyme MB (CK MB), high-sensitivity troponin I (TNI), interventricular septum thickness (IVST), and left ventricular ejection fraction (LVEF) were independent predictors of renal impairment (p<0.05).
  • A combined risk score demonstrated strong predictive power for future renal function damage (p<0.05).
  • Receiver operating characteristic (ROC) curve analysis showed an area under the curve of 0.849 (P<0.001) for the risk score.

Conclusions:

  • Left ventricular ejection fraction (LVEF) and interventricular septum thickness (IVST) predict adverse renal outcomes in essential hypertension.
  • A simplified risk score combining key variables aids in early assessment of renal impairment risk in hypertensive patients.
Abstract

Keywords:
changes of cardiac structure and functionechocardiographyhypertensionhypertensive nephropathyprogression of renal damage

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