Assessment of Chemotherapy-Induced Cardiac Dysfunction in Breast Cancer Patients: A Prospective Study
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View abstract on PubMed
Summary
This summary is machine-generated.Chemotherapy can cause heart problems, but early detection and treatment improve recovery. Acute cardiotoxicity in breast cancer patients is manageable with timely interventions.
Area Of Science
- Cardiology
- Oncology
- Pharmacology
Background
- Cancer therapies improve survival but increase treatment-related side effects.
- Acute cardiac toxicity from chemotherapy lacks sufficient predictive literature.
- Cardiovascular complications, particularly cardiac dysfunction, are significant concerns in breast cancer patients undergoing therapy.
Purpose Of The Study
- To evaluate the incidence, timing, and clinical factors of chemotherapy-related cardiac dysfunction (CTRCD) in breast cancer patients.
- To assess global longitudinal strain (GLS) and response to heart failure (HF) therapy in patients with cardiotoxicity.
- To emphasize therapy-related cardiac dysfunction in breast cancer treatment.
Main Methods
- Prospective observational study of 97 breast cancer patients from March 2020 to October 2021.
- Assessment of left ventricular ejection fraction (LVEF) at baseline, mid-, and post-chemotherapy.
- Modification of chemotherapy and initiation of HF therapy for patients developing left ventricular dysfunction (LVD).
Main Results
- Chemotherapy-related cardiac dysfunction (CTRCD) occurred in 13.4% of patients (13/97).
- Higher risk of LVD was associated with ER+, PR+, HER2+ status and cancer stages III-IV.
- Among affected patients, 77% had complete cardiac recovery; partial recovery was linked to advanced cancer stages and lower treatment intensity.
Conclusions
- Acute cardiotoxicity is not directly correlated with cumulative anthracycline dosage.
- Early detection of CTRCD, chemotherapy regimen adjustment, and prompt HF therapy significantly improve cardiac function recovery.
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